![]() Khan, Nealia Dryden-Peterson, Scott Bennett, Kara Wirth, Kathleen E. Personal Author(s) : Novitsky, Vlad Gaolathe, Tendani Mmalane, Mompati Moyo, Sikhulile Chakalisa, Unoda Yankinda, Etienne Kadima Marukutira, Tafireyi Holme, Molly Pretorius Sekoto, Tumalano Gaseitsiwe, Simani Musonda, Rosemary van Widenfelt, Erik Powis, Kathleen M. Including ARV in RITA2 improved the accuracy of HIV-1 incidence estimates by removing participants with likely long-term HIV infection.ĬITE Title : Lack of Virological Suppression among Young HIV-Positive Adults in Botswana Incidence estimates were similar using detectable or self-reported ARV (R2>0.995). RITA2 incidence was lower than RITA1 incidence (range, 0%–30% decrease), resulting in decreased estimated new infections from 390,000 to 341,000 across the 13 countries. 10%) and had higher levels of drug resistance (74% vs. Those with detectable ARV were significantly more likely to be aware of their HIV-positive status (84% vs. RITA2 reclassified 55 (15.4%) persons with detectable ARV as having long-term infection. Overall, 357 adult HIV-positive participants were classified as having recent infection with RITA1. ![]() We explored RITA2 with self-reported ARV use and with clinical history. We compared HIV-1 incidence estimates using two RITA RITA1: LAg-recent + VL ≥1000 copies/mL and RITA2: RITA1 + undetectable ARV. LAg-recent result was defined as normalized optical density values ≤1.5. HIV-seropositive samples were tested for recency using the HIV-1 Limiting Antigen (LAg)-Avidity enzyme immunoassay, HIV-1 viral load, ARVs used in each country, and ARV drug resistance. We used data from 13 African household surveys to describe the impact of an ARV-adjusted RITA on HIV-1 incidence estimates. However, persons with recent classification not virally suppressed and taking antiretroviral medication (ARV) may be misclassified. HIV-1 incidence calculation currently includes recency classification by HIV-1 incidence assay and unsuppressed viral load (VL≥1000 copies/mL) in a recent infection testing algorithm (RITA). 87, 2021 Export RIS Citation Information. "HIV-1 Recent Infection Testing Algorithm with Antiretroviral Drug Detection to Improve Accuracy of Incidence Estimates" vol. "HIV-1 Recent Infection Testing Algorithm with Antiretroviral Drug Detection to Improve Accuracy of Incidence Estimates" 87 (2021) Voetsch, Andrew C. HIV-1 Recent Infection Testing Algorithm with Antiretroviral Drug Detection to Improve Accuracy of Incidence Estimates. Mwesigwa, Richard Balachandra, Shirish Lobognon, Roger Kampira, Elizabeth Detorio, Mervi Yufenyuy, Ernest L. Bissek, Anne-Cécile Zoung-Kanyi Kingwara, Leonard Junghae, Muthoni Kiiru, John N. ![]() Malewo, Optatus Mushi, Jeremiah Payne, Danielle Mengistu, Yohannes Asiimwe, Fred Shang, Judith Dokubo, Emily Kainne Eno, Laura T. Dlamini, Sindisiwe Nuwagaba-Biribonwoha, Harriet Pasipamire, Munyaradzi Tegbaru, Belete Eshetu, Frehywot Biraro, Sam Ward, Jennifer Aibo, Dorothy Kabala, Andrew Mgomella, George S. Mengistu, Assegid Mugurungi, Owen Chikwanda, Prisca Musuka, Godfrey Ndongmo, Clement B. Stupp, Paul Saito, Suzue McCracken, Stephen Dobbs, Trudy Winterhalter, Frieda S. CITE Title : HIV-1 Recent Infection Testing Algorithm with Antiretroviral Drug Detection to Improve Accuracy of Incidence Estimates
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